BQ-123 SODIUM SALT

Name	BQ-123 SODIUM SALT
Synonyms	BQ-123 BQ-123 SODIUM SALT ETA-RECEPTOR ANTAGONIST C(DTRP-DASP-PRO-DVAL-LEU) cyclo(Trp-Asp-Pro-Val-Leu) CYCLO(D-ASP-PRO-D-VAL-LEU-D-TRP) CYCLO (D-ALPHA-ASPARTYL-L-PROLYL-D-VALYL-L-LEUCYL-D-TRYPTOPHYL)
CAS	136553-81-6

Molecular Formula	C31H42N6O7
Molar Mass	610.7
Density	1.33±0.1 g/cm3(Predicted)
Boling Point	1053.6±65.0 °C(Predicted)
Appearance	lyophilized powder
pKa	4.04±0.10(Predicted)
Storage Condition	-20°C
In vitro study	In porcine aortic vascular smooth muscle cells, BQ-123 selectively inhibited ETA-mediated contraction. In rat vascular smooth muscle cells, BQ-123 inhibited inositol phosphate breakdown and DNA synthesis induced by endothelin-1.
In vivo study	In rats, BQ-123 (1 mg/kg, I. v.) ameliorated myocardial ischemia-reperfusion injury. In rats with pentylenetetrazol (PTZ)-induced tonic-clonic seizures, BQ-123 (3 mg/kg, I. v.) effectively prevented the formation and development of epilepsy. In pregnant C57BL/6 mice, BQ-123 (6.7 mg/kg, I. p.) prevented LPS-induced preterm birth in mice by inducing IL-10 in the uterus and placenta.

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3

Last Update：2024-01-02 23:10:35

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CAS: 136553-81-6
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Product Name: BQ-123 SODIUM SALT Visit Supplier Webpage Request for quotation
CAS: 136553-81-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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BQ-123 SODIUM SALT

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